Harnessing the Gut Microbiome to Unlock Anti-Tumor Immunity

We are pleased to announce that Dr. Ze'ev Ronai, from Cedars-Sinai Health Sciences University, USA, will join 13th World Congress on Targeting Microbiota - ISM 2026 as a speaker.

This presentation will provide an example of how the gut microbiota can induce anti-tumor immunity and limit tumor growth through specific bacterial strains, such as Bacteroides rodentium in mice and Bacteroides uniformis in humans. These bacteria metabolize tryptophan into indoles, including indole and its derivatives, which are themselves sufficient to recapitulate the anti-tumor effects of the selected bacterial strains. Notably, the enzymes that mediate tryptophan metabolism, TnaA and ArAT, are more abundant in patients who respond to immune checkpoint therapy. The potential implications of these findings for patient care and the development of microbiota-based therapeutic strategies will also be discussed.