Aging from Within: Microbiota-Induced Vascular Senescence
Researchers found that levels of phenylacetic acid (PAA)—a metabolite produced by certain gut bacteria—are significantly elevated in older adults and aged mice. This rise is associated with specific microbial pathways and correlates with endothelial dysfunction.
The study demonstrates that PAA promotes EC senescence by increasing mitochondrial hydrogen peroxide (H₂O₂) levels, triggering inflammation and impairing blood vessel formation. Importantly, the research also shows that supplementing with acetate can counteract the harmful effects of PAA, restoring endothelial function and pointing to potential therapeutic strategies for promoting vascular health with age.
These findings underscore the vital role of gut health in aging and cardiovascular disease prevention, and they open the door to microbiota-based therapies aimed at improving cardiovascular outcomes in older adults.
This topic will be discussed during Targeting Microbiota 2025, which will be held in Valencia, Spain, and the first Riken-ISM meeting in Tokyo, Japan.
You still have time to submit your abstract for Short or Poster communication.
