Metabolic and Metagenomic Consequences of E. coli Infections

Matteo SERINO Targeting Microbiota 2019The Scientific Committee of Targeting Microbiota 2019 Congress invited Dr. Matteo Serino from Inserm and Digestive Health Research Institute, France.

Dr. Serino will give a presentation entitled "Metabolic and Metagenomic Consequences of E. coli Infections".

Summary of Presentation: A dietary fat enrichment is among the strongest factors impacting on gut microbiota on a both structural and functional level, as well known as inducer of metabolic diseases such as obesity, type 2 diabetes and hepatopathology. Interestingly, an alimentary switch towards the high-fat content has been also shown  capable of favouring the colonisation of the intestine by enterobacteria. Among the latters are pro-inflammatory and/or genotoxic E. coli strains. The metabolic consequences of the infections by these bacteria in mice will be discussed in relation to a lean vs. an obese/diabetic host, together with changes in the gut microbiota and microbiome.

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