Microbial and Nutritional Influence on Endocrine Control of Growth

Dr François LeulierDr. François Leulier from Université de Lyon, France will be discussing his most recent findings on “Microbial and Nutritional Influence on Endocrine Control of Growth" in a session dedicated to “Personalized Nutrition and Microbiota”.

Metazoans establish reciprocal interactions with their commensal bacterial communities. Despite recent progress, a clear view of the physiological benefits associated with host/microbiota relationship remains elusive. Hence the molecular mechanisms through which the microbiota exerts its beneficial influences are still largely undefined.

In this line, he aims at deciphering the molecular dialogue governing the mutualistic interaction between intestinal bacteria and their host. To this end, he is using a genetically tractable gnotobiotic animal model: Drosophila melanogaster, which are associated to its natural dominant commensals, Lactobacillus plantarum and Acetobacter pomorum. He is developing multiscale functional approaches to identify the mechanisms that underlie their mutualistic relationship, which results in the promotion of host juvenile growth.

His approaches aim at identifying both the bacterial and host genetic and metabolic networks required to sustain their mutualistic relationship. In addition, he is translating his discoveries to mouse gnotobiotic and conventional models by studying the impact of selected strains or newly developed minimal communities of intestinal bacteria on mice linear growth.

He will present his latest results using Drosophila and Mouse models.

Remember that you can also participate in the “Nutrition, Water and Microbiota: The Missing Links” session by submiting your abstract here.

Targeting Microbiota 2022 Congress
October 19-21, 2022- Paris, France



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