Short-chain Fatty Acids as Modulators of Redox Signaling in Health and Disease

Dr Carmen González BoschDr. Carmen González-Bosch, from Universitat de València, Spain will be discussing her most recent findings on ''Short-chain Fatty Acids as Modulators of Redox Signaling in Health and Disease''.

It is now apparent that the microbiota is a critical determinant of human health and disease and a key regulator of host physiology. Several health benefits of specific food-derived molecules are related to their ability to activate antioxidant defences. Among these, is the well-studied isothiocyanate sulforaphane, found in cruciferous vegetables such as broccoli.

This protection occurs through activation of the Nuclear erythroid 2-related factor 2 (NRF2)-KEAP1 pathway, in which NRF2 serves as a master regulator of cellular antioxidant defences. Notably, short chain fatty acids, such as butyrate and propionate, produced by colonic bacteria and obtained from the diet, are also activators of NRF2, although studies on their role as regulators of redox homeostasis is limited.

Dr. González-Bosch recently critically reviewed this field, providing convincing evidence supporting their cytoprotective roles in suppressing inflammation and carcinogenesis and the consequences of aging.

The fact that phytochemicals, including sulforaphane, activate similar redox-sensitive genes in both plant and mammalian cells, prompted us to initiate a translational research project in collaboration with colleagues at King´s College of London with the objective of integrating knowledge from priming plants and mammalian cells based on redox homeostasis.

The design of improved experimental approaches to explore the mechanisms of production and action of SCFAs in cellular redox signaling under physiological oxygen levels will underpin strategies for developing personalized nutrition and therapeutics for redox medicine.

The Targeting Microbiota 2022 Congress, held this October - in Paris, will be hosting similar interesting topics on microbiota.

Targeting Microbiota 2022 Congress
October 19-21, 2022 - Paris, France

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