Role of microbes in stem cells transplantation related complication

Pr Ernst Holler Microbiota 2018 Speaker

Prof. Ernst Holler from University Hospital Regensburg, Germany will join the 6th World Congress on Targeting Microbiota 2018 and will talk about "Role of microbes in stem cells transplantation related complication" during the congress.

Summary of presentation: "Haematopoietic stem cell transplantation is a curative treatment optionin patients with leukemia but can be complicated by life threatenningGraft-versus-Host Disease (GvHD) especially in the gastrointestinal (GI)tract. In the last 5 years, early and severe disruption of theintestinal microbiota has been identified as a major risk factor ofGI-GvHD.  Broad spectrum antibiotics applied for neutropenic infectionsbut also destruction of Paneth cells by GvHD itself are major factorsresulting in dysbiosis which strongly enhances intestinal inflammationinduced by donor cells. Lack of protective metabolites such as shortchain fatty acids and indoles produced by commensal explains thisassociation but direct microbiota – T cell interactions maycontribute. Restoration of a protective microbiome may become analternative approach for treatment and prevention of GI-GvHD."


To know more about Targeting Microbiota 2018 Congress, please check the Agenda here

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