Link between microbiota & visceral pain: role of bioactive lipids

Microbiota 2018 Speaker Cenac Nicolas

Dr. Nicolas Cenac from Inserm, France will join the 6th World Congress on Targeting Microbiota 2018 Congress and give presentation about "Link between microbiota & visceral pain: role of bioactive lipids".

"Impairment in the composition and diversity of this microbiota have been observed in pathologies of digestive tract such as irritable bowel syndrome (IBS). In order to study the impact of bacteria on the most deleterious IBS symptoms, visceral pain, we used several approaches in mass spectrometry to analyze bacterial lipids. We highlighted the production by bacteria of lipopeptides able to cross the intestinal barrier to regulate sensory neurons. In addition, we characterized several long chain fatty acid (LCFA) modifying the production of pro-algesic molecules by intestinal epithelial cells. These works allowed us to demonstrate that bacteria from the microbiota, by secreting lipopeptides and LCFAs, could signal directly or via the epithelium to sensory neurons."


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