Prof. Jan Mazela, Poznan University of Medical Sciences awarded by International Society of Microbiota

Mazela targeting Microbiota 2018

Press release - December 12, 2018, Tokyo, Japan: 

International Society of Microbiota (ISM) announces the winner of the prestigious award for his exceptionnal scientific and medical contribution for the year 2018, Prof. Jan Mazela from Poznan University of Medical Sciences, Poland.

Prof. Mazela gave a major communication during the 6th World Congress on Targeting Microbiota 2018, which was held in Porto, Portugal. 

Prof. Mazela presented stragetic talk concerning "Targeted gut microbiota and short chain fatty acid profile amoung term and preterm infants".

Oral presentation of Prof. Mazela during Targeting Microbota 2018:

Gut dysbiosis can be responsible for many diseases such as NEC, celiac disease, obesity, chronic enetrocolitis, Crohns disease, irritable bowel syndrome, infantile colic, atopic dermatitis, autism, depression and autoimmune diseases, and finally non-comunicable diseases. Thus very crucial is initial priming of the neonatal digestive system with optimal microbiota. There is substantial new information on the role of first 1000 days from conception on the development of optimal microbiome and human body programming.  There are several perinatal factors which can influence initial neonatal bacterial priming, such as: nutrition during pregnancy, gestational age, mode of delivery, perinatal antibiotic therapy, nicotine exposure during pregnancy. So far probiotic therapies both in term and preterm infants were focused on use of two bacterial genera: Lactobacillus and Bifidobacterium. Thus the aim of our research was to identify bacterial strains colonized among term and preterm infants in the first days of life and to establish the role of the gestational age and mode of delivery on the neonatal microbiota and short chain fatty acid (SCFA) profile with reference arm of the microbiota of the newborns born at home.

Prof. Peter Konturek, Teaching Hospital of the University of Jena, Germany, President of ISM stated that Prof. Mazela found out that none of the meconium sample was sterile. Microbiota profile of the term infants‘ meconium had higher amounts of the following bacteria: E. coli, Enterococcus, Lactobacillus and Bifidobacterium, in comparison to premature infants. After 6 weeks being home premature infants had higher level of: Enterobacteriaceae, and term infants had higher level of Bacteroides. When mode of the delivery was analysed, it has been shown that vaginally delivered term infants had higher levels of E. coli, Enterococcus, Lactobacillus, Bifidobacterium in the meconium and they had more Bacteroides in the stool after 6 weeks being home in comparison to preterm infants. On the other hand preterm infants had higher levels of Enterobacteriaceae, Faecalibacterium prausnitzii and total bacterial count. Infants delivered by c-section when born at term had higher levels of Bifidobacterium in the meconium than preterm but this difference was not seen any more in the stool after 6 weeks being home. When analyzed samples from infants born at home the only difference between vaginally delivered in the hospital and at home was the level of F. prausnitzii which was higher among those born at home. There was more E.coli in the stool after being home for 6 weeks among those born in the hospital vs. born at home. Analysis of SCFA revealed no difference in SCFA levels between prematurely born as well as delivered at term in meconium, as well as lack influence on SCFA by the mode of delivery. Besides it has been shown that acetate levels doubled, propionate achieved hundred times higher levels, butyrate and valerate doubled to quadrupled after being home for 6 weeks in term and preterm infants when compared to levels in meconium.  

Prof. Mazela concluded that vaginal delivery is preferred mode of delivery assuring the most optimal microbiota priming both for premature as well as mature infants which can be observed in the stool profile at 6 weeks of being home. Microbiota of the term and born at home infants is more stable in comparison to those born in the hospital. There is need to continue studies on the role of home delivery on the neonatal microbiota. In summary, it can be speculated that infants born at the GPSK in Poznan can benefit by multistrain probiotic supplementation initially with E. coli and followed by Bifidobacterium, Lactobacillus, Enterococcus if born prematurely. Further studies should establish safety and efficacy profile of such therapeutic approach. The group is now studying also the safety and efficacy of the vaginal seeding procedure on term and prematurely born infants. 

Prof. Marvin Edeas, University Paris Descartes, France, chairman of the scientific committee, highlighted the role of Prof. Mazela at Internatiobal Society Microbiota community: We congratulate Prof. Jan Mazela for his contribution in the microbiota medicine, his vision and energy in the field of microbiota in preterm infant open the door to new strageties.

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