Alerts

Interpreting Microbiomes Via Multi-omics for Precision Health

Dr Nathan PriceDr. Nathan Price, from Thorne HealthTech, USA will be discussing his most recent findings on ''Interpreting microbiomes via multi-omics for precision health''

Healthcare in the 21st century is becoming increasingly focused on wellness as a key strategy for dealing with the chronic diseases that account for the majority of healthcare costs today. To enable the precision health strategies of the future — what we call ’scientific wellness’ — it is necessary to generate large amounts of data on healthy people to quantify wellness states and to observe the earliest transitions to disease in order to enable predictive and preventive medicine.

In his talk, Dr. Price will discuss how such 'deep phenotyping’ data has been used in particular to show:

  1. The ability of the blood metabolome to interpret key aspects of gut microbiome health
  2. The gut microbiome becoming more unique to each individual throughout healthy aging
  3. Intervening in the microbiome to improve health.

He will also introduce a new microbiome sample collection technology that his team developed at Thorne HealthTech.

Join us for Targeting Microbiota 2022, this October - in Paris, to know more about similar interesting topics on microbiota.

Targeting Microbiota 2022 Congress
October 19-21, 2022 - Paris, France
www.microbiota-site.com

Understanding the Heterogeneity of Host-associated Microbial Communities

Dr Lei DaiProf. Lei Dai, from Shenzhen Institutes of Advanced Technology (China), will be discussing his most recent findings on ''Understanding the Heterogeneity of Host-associated Microbial Communities''

The realization that microbial communities, associated with virtually all multicellular organisms, have tremendous impact on their hosts’ health and development is considered one of the most important scientific discoveries in the last decade.

Prof. Dai will introduce his recent efforts to characterize the heterogeneity of host-associated microbiome in three different aspects:

1) Dynamics. There is growing evidence that baseline composition may be an important contributor to the personalized response of gut microbiome. Prof. Dai developed computational approaches to study key factors underlying the heterogeneity in microbiome dynamics.

2) Space. The spatial heterogeneity of microbial communities has been observed across different habitats, ranging from human gastrointestinal tract to plant rhizosphere. He developed in situ spatial analysis of microbiome at single cell resolution, which is crucial for elucidating the principles governing the assembly of microbiome.

3) Strain. The within-species functional heterogeneity has been increasingly recognized as an important factor in shaping the ecology and evolution of microbiome. He developed bioinformatics tools to infer strain-level composition and functional profiles from metagenomics data.

In summary, Prof. Dai developed novel methods to study the dynamical response, spatial structure and strain-level diversity of microbial communities. These methods will open up new dimensions to understand the complexity of microbiome and facilitate the precise engineering of microbiome.

Targeting Microbiota 2022 Congress
October 19-21, 2022 - Paris, France
www.microbiota-site.com

Gut Microbiota-Derived Extracellular Vesicles on Obesity, Diabetes and Metabolism

Dr Fermin I. Milagro

Dr. Fermin I. Milagro, from the University of Navarra (Spain), will be discussing his most recent findings on "Gut Microbiota-Derived Extracellular Vesicles on Obesity, Diabetes and Metabolism".

Gut microbiota dysbiosis has been proposed as a contributing factor to the etiology of obesity and diabetes. In this context, gut microbiota-derived extracellular vesicles (EV) are gaining attention as mediators in the gut microbiota-host communication. EV derived from gut microbiota and probiotic bacteria contain a myriad of bioactive molecules (including proteins, microRNAs, and lipids) that could modulate important biological functions with overall impact on host health. It has been reported that EV-derived from specific bacteria induce different physiological responses. For example, those from Akkermansia muciniphila are known to ameliorate obesity and diabetes in mice. Some of the underlying mechanisms are the modulation of gut permeability, inflammation, and host metabolism. For these reasons, nutritional and pharmacological approaches based on the administration of EV derived from probiotics or gut microbiota bacteria should be viewed as a new therapeutic tool to treat obesity and diabetes. Also, the characteristics and amount of gut microbiota-derived EV could be modulated through dietary means to prevent and treat metabolic diseases.

Targeting Microbiota 2022 Congress
October 19-21, 2022 - Paris, France
www.microbiota-site.com

 

Microbial and Nutritional Influence on Endocrine Control of Growth

Dr François LeulierDr. François Leulier from Université de Lyon, France will be discussing his most recent findings on “Microbial and Nutritional Influence on Endocrine Control of Growth" in a session dedicated to “Personalized Nutrition and Microbiota”.

Metazoans establish reciprocal interactions with their commensal bacterial communities. Despite recent progress, a clear view of the physiological benefits associated with host/microbiota relationship remains elusive. Hence the molecular mechanisms through which the microbiota exerts its beneficial influences are still largely undefined.

In this line, he aims at deciphering the molecular dialogue governing the mutualistic interaction between intestinal bacteria and their host. To this end, he is using a genetically tractable gnotobiotic animal model: Drosophila melanogaster, which are associated to its natural dominant commensals, Lactobacillus plantarum and Acetobacter pomorum. He is developing multiscale functional approaches to identify the mechanisms that underlie their mutualistic relationship, which results in the promotion of host juvenile growth.

His approaches aim at identifying both the bacterial and host genetic and metabolic networks required to sustain their mutualistic relationship. In addition, he is translating his discoveries to mouse gnotobiotic and conventional models by studying the impact of selected strains or newly developed minimal communities of intestinal bacteria on mice linear growth.

He will present his latest results using Drosophila and Mouse models.

Remember that you can also participate in the “Nutrition, Water and Microbiota: The Missing Links” session by submiting your abstract here.

Targeting Microbiota 2022 Congress
October 19-21, 2022- Paris, France
www.microbiota-site.com

 

 

Precision Nutrition to Modulate Gut Microbiota in Reproductive Health and Pregnancy

Dr Annalisa TerranegraDr. Annalisa Terranegra from Sidra Medical and Research Center, Qatar, will be discussing her most recent findings on ”Precision nutrition approach to modulate gut microbiota in reproductive health and pregnancy"

A poor diet during preconception period and pregnancy can cause deficiency in nutrients impacting on gene pathways involved in the metabolism, immune system, angiogenesis and other pathways and leading to infertility, pregnancy complications (i.e., gestational diabetes, gestational hypertension, preterm birth, etc.) and the risk of non-communicable diseases (NCD) in the adult life.
The recent advance in the multi-omics technologies opens new routes to discover the molecular mechanisms underlying the role of nutrients in fertility and pregnancy complications.
The study of the microbiota shed lights on the microbial dysbiosis caused by unbalanced diet and its link with pregnancy complications, such as gestational diabetes and preterm birth, among others. However, the difference in genetic background as well as in the environmental factors makes difficult to define the exact mechanism controlling the microbiota in the pregnancy complications and infertility among different populations. The science of precision nutrition aims to provide precise diagnosis and personalized treatments to the individual patient taking into account genetics, microbiota composition and environmental factors.
Her studies focus on understanding the response of the gut microbiota to different dietary intakes both in pregnancy complications and in-vitro fertilization treatments in unexplored populations from Middle East and Far East.

You can also present a short oral presentation during this session, by submitting your abstract here.

Targeting Microbiota 2022 Congress
October 19-21, 2022- Paris, France
www.microbiota-site.com

Exploring a Healthy Human Gut Microbiota in a Mediterranean Cohort

Dr Andrés MoyaDr. Andrés Moya from the University of València, Spain will join us this year to present his most recent findings on "Exploring a healthy human gut microbiota in a Mediterranean cohort"

In his talk, he will present his recent study where he characterize the composition and function of the gut microbiota of a healthy Mediterranean cohort structured in three groups of age (Infants, Adults, and Elderly). This cohort has been sampled regularly for up to more than two years. He will report on a set of mutualistic symbionts constituting the microbial core of the Mediterranean cohort across the entire life. Also, he will present robustness differences of the gut microbiota at different age periods and the existence of taxa, particularly at elderly, decoupled from and do not favor their host.

Targeting Microbiota 2022 Congress
October 19-21, 2022- Paris, France
www.microbiota-site.com

 

Best Short Oral Presentation Awards 2021

Microbiota Congress 2021

35 Short Oral Presentations were communicated during the 8th World Congress on Targeting Microbiota 2021, held on October 20-22. 

The scientific committee nominated 7 presentations for the Best Short Oral Presentation Awards of 2021:

Postbiotic Metabolite - Uroloithin A as a Lead Molecule for Atopic Dermatitis
Sebastian Granica, Medical University of Warsaw, Poland

Biotransformation of the Constituents of Medicinal Plants Used in the Urinary Tract Infections by Human and Pig Gut Microbiota
Dominik PopowskI, Medical University of Warsaw, Poland

Synthetic Derivatives of Urolithin A Increase CACO-2 Monolayer Integrity, Impede Intestinal Glucuronidation, and Suppress TNF Alpha Production in THP-1 Derived Macrophages
Maciej Korczak, Medical University of Warsaw, Poland

Generation of Microbial Compositions From 16S rRNA Sequences — Are You Generating Medically Meaningful Analyses?
Eric Nayman, Herbert Wertheim College of Medicine, USA

A Systematic Review on the Latest Development of Probiotics Intervention as Prevention and Therapy for Covid-19 Infection
Learn-Han Lee, Monash University Malaysia, Malaysia

Gut Microbiome Predicts Clinically Important Improvement in Patients with Rheumatoid Arthritis
Jaeyun Sung, Mayo Clinic, USA

Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials
Ahmad Saedisomeolia, McGill University, Canada

 


Winners of the Best Short Oral Presentations - Targeting Microbiota 2021

Targeting Microbiota 2021 Award Sebastian GranicaPostbiotic Metabolite - Uroloithin A as a Lead Molecule for Atopic DermatitisSebastian Granica, Medical University of Warsaw, Poland

 

 

Targeting Microbiota 2021 Award Jaeyun SungGut Microbiome Predicts Clinically Important Improvement in Patients with Rheumatoid Arthritis - Jaeyun Sung, Mayo Clinic, USA

In the years ahead, Dr. Sung's research group will continue working on ways to apply personalized microbiome data for disease diagnostics and predictive analytics.

 

Targeting Microbiota 2021 Award Eric NaymanGeneration of Microbial Compositions From 16S rRNA Sequences — Are You Generating Medically Meaningful Analyses? - Eric Nayman, Herbert Wertheim College of Medicine, USA

“As we are becoming increasingly aware of the vital role that indigenous human microbiota plays in regulating host health and behavior, we must improve our ability to prove causality in this relationship, which is what I intend to keep contributing toward.”


Targeting Microbiota 2021 Congress
October 20-22, 2021 - Interactive Online
www.microbiota-site.com

 

Best Poster Presentation Awards 2021

Microbiota_Congress_2021.jpg

Out of 24 Poster Presentations communicated during Targeting Microbiota 2021, the scientific committee nominated 7 posters for the Best Poster Presentation Awards of 2021:

Dietary Supplementation with Spray-Dried Porcine Plasma Has Prebiotic Effects on Gut Microbiota in Senescent Mice
Cristina Rosell-Cardona, Universitat de Barcelona, Spain

The Impact of Early-Life Antibiotic Exposure on the Behaviors and Gut Microbiota in Mice
Yuan Yuan Lin, Cheng Kung University, Taiwan

Gut-Derived Indole-3-Propionic Acid May Modulate the Mitochondrial Organization in Hepatic Stellate Cells
Mariana Ilha, University of Eastern Finland, Finland

Selection of Psychobiotic Microorganisms and Development of a Dietary Supplement with Potential Effect on Mental Health
Melania Casertano, University of Naples Federico II, Italy

Research on Natural Products Applied in Anxiety and Mood Disorders with Regard to Gut Microbiota
Aleksandra Gorczyńska, Medical University of Warsaw, Poland

The Probiotic Yeast Saccharomyces boulardii CNCM I-745 Prevents Invasion of Vaginal Epithelial Cells by Candida albicans and Gardnerella vaginalis
Philippe Tixador, Biocodex, France

Gut Microbiota-Mediated Glucagon-Like Peptide-1 Modulates Locomotor Activity via Vagal-Dependent Pathway
Tzu-Ting Lai, National Cheng Kung University, Taiwan

 


Winners of the Poster Presentations - Targeting Microbiota 2021

Targeting Microbiota 2021 Award Mariana IlhaGut-Derived Indole-3-Propionic Acid May Modulate the Mitochondrial Organization in Hepatic Stellate Cells Mariana Ilha, University of Eastern Finland, Finland

“Receiving this award was very nice and gives me more energy and confidence to continuous my research about the influence of the gut derived metabolite indole-3- propionic acid in mitochondrial function and future possible compound for the resolution of liver fibrosis”

 

Targeting Microbiota 2021 Award Cristina Rosell CardonaDietary Supplementation with Spray-Dried Porcine Plasma Has Prebiotic Effects on Gut Microbiota in Senescent Mice - Cristina Rosell-Cardona, Universitat de Barcelona, Spain

"Currently, my research is focused on the effects of spray-dried plasma proteins on microbiota composition and its neuroprotective effects against Alzheimer’s disease hallmarks in senescent mice. Next year, I would like to study if these effects are linked through the gut-brain axis. Personally, I am about to finish my PhD and I am looking forward to finding new opportunities to develop my research career, improve my skills, and look deeply into the gut-brain axis field."

 

Targeting Microbiota 2021 Award Philippe ToxadorThe Probiotic Yeast Saccharomyces boulardii CNCM I-745 Prevents Invasion of Vaginal Epithelial Cells by Candida albicans and Gardnerella vaginalis - Philippe Tixador, Biocodex, France

“For the next year, we would like to complete this study notably by characterizing the mechanisms which promote the beneficial effects of S.boulardii CNCMI-745 in the treatment of the vulvovaginitis and publish all these data in a peer-to-peer scientific journal.”

All authors


Targeting Microbiota 2021 Congress
October 20-22, 2021 - Interactive Online
www.microbiota-site.com

 

Scientific Awards of Targeting Microbiota 2021

Microbiota banner online

Targeting Microbiota 2021 was successully held on October 20-22 2021, as an Interactive Online meeting. 

At the end of the congress, the scientific committee decided to award some speakers for their excellent contribution. 

 

Scientific Award #1

Targeting Microbiota 2021 Rosa Krajmalnik Brown07After an excellent and special talk about "Microbiota Transfer Therapy for Autism: Multi-Omic Approaches and Lessons Learned", Dr. Rosa Krajmalnik-Brown was discerned the Trageting Microbiota 2021 Scientific Award. 

Dr. Krajmalnik-Brown gave an overview on her achievements and perspective in Autism Disorders. She is the director of the Biodesign Center for Health Through Microbiomes and a Professor at the School of Sustainable Engineering and The Built Environment, at Arizona State University, USA.

She is a pioneer in research on gut microbiome and autism. She is author of 4 patents and more than 115 peer-reviewed publications.  Dr. Krajmalnik-Brown specializes on molecular microbial ecology for bioremediation, the use of microbial systems for bioenergy production, and the human intestinal microbial ecology and its relationship to obesity, bariatric surgery, metabolism, and autism.

 


 

Scientific Award #2

Targeting Microbiota 2021 KosticDr. Aleksander Kostic was also the winner of a scientifc award for his presentation about Reconstruction of Ancient Microbial Genomes from the Human Gut

Dr. Aleksandar Kostic along with his team have shown that industrial lifestyles are correlated with both a lower diversity in the gut microbiome and increased incidence of chronic diseases, such as obesity and autoimmune diseases. Examining our ancestral gut microbiome may provide insights into aspects of human–microbiome symbioses that have become altered in the present-day industrialized world. Reconstruction of metagenome-assembled genomes (MAGs) is an emerging approach to recover high-quality genomes and previously undescribed species-level genome bins (SGBs) from shotgun metagenomics data. Sequencing reads are de novo assembled into contiguous sequences (contigs), and contigs are binned to form draft genomes.

 


 

Scientific Award #3

Targeting Microbiota 2021 Award 1Prof. Siew Ng gave a presentation on The Promise of Microbiota Modulation during COVID-19 Pandemic, for which she was discerned a scientific award.

Siew Ng is Director of Microbiota I-Center (MagIC) of the Chinese University of Hong Kong. She and her team were the first to report the role of the gut microbiome in COVID-19 and they have developed a novel microbiome immunity consortia to hasten recovery and restore dysbiosis in COVID-19 and its sequele leading to global impact.

 


 

Animal Microbiota Symposium Scientific Award 

Targeting Microbiota 2021 Andres GomezDuring the session on Targeting Animal Microbiota Symposium, Dr. Andres Gomez was discerned a scientific award for his presentation on 

This study, in collaboration with Dr Krishona Martinson- University of Minnesota, was initially conducted to asses whether a reduced lignin (RL) version of alfalfa (8% less compared with the standard version (SV)) improved feed digestibility in horses. The data showed that the incorporation of RL alfalfa in horse diets increased apparent dry matter digestibility; but did not change mean fecal particle size, apparent crude protein digestibility, or mean retention time. When analyzing the fecal microbiome of the horses, when shifting from RL to SV of alfalfa, there were no apparent changes. However, we realized that each horse had a unique microbiome, which responded in an individual and significant manner to the content of lignin in alfalfa. These horse-unique patterns also correlated with individual outcomes in other feed digestibility traits, such as apparent dry matter digestibility and mean fecal particle size, all of which fluctuated differently in each horse. The study shows that horses have highly individualized microbiomes, which may determine individual responses to different types of feed. In other words, dietary interventions in horses trigger individualized microbiome responses, and hence the effects and benefit of some diets ands ingredients may be horse-specific. These results open the door to consider individualized nutrition strategies in companion and food animals.

 


 

Targeting Microbiota 2021 Congress
October 20-22, 2021 - Interactive Online
www.microbiota-site.com

 

 

 

 

 

Microbiota Transfer Therapy for Autism: Multi-Omic Approaches and Lessons Learned

Targeting Microbiota 2021 Rosa Krajmalnik Brown07The International Society of Microbiota is pleased to invite Dr. Rosa Krajmalnik-Brown to provide an Inaugural talk on "Microbiota Transfer Therapy for Autism: Multi-Omic Approaches and Lessons Learned". Dr. Rosa Krajmalnik-Brown will overview her achievements and perspective in Autism Disorders. She is the director of the Biodesign Center for Health Through Microbiomes and a Professor at the School of Sustainable Engineering and The Built Environment, at Arizona State University, USA.

Read more...

Role of Microbiota-Gut-Brain Axis Dysfunctions Induced by Infections in the Onset of Anorexia Nervosa

Targeting Microbota 2021 Marie GalmicheDr. Marie Galmiche, from Normandie University, France, will join Targeting Microbiota 2021. 

Dr. Galmiche will give a talk about "Role Of Microbiota-Gut-Brain Axis Dysfunctions Induced by Infections in the Onset of Anorexia Nervosa"

Targeting Microbiota 2021 Congress
October 20-22, 2021 - Paris, France & Online
www.microbiota-site.com

 

Tryptophan Metabolism in Gut Microbes and Brain Axis

Targeting Microbiota 2021 Wei yun Zhuj.pg

Prof. Wei-Yun Zhu from College of Animal Science and Technology, Nanjing Agricultural University, China will join the Targeting Microbiota 2021 congress which will be held on October 20-22, 2021 and will provide a talk concerning "Tryptophan Metabolism in Gut Microbes and Brain Axis".

Prof. Zhu confirms that the bilateral communication network between the gastrointestinal (GI) tract and the central nervous system is regards as the gut-brain axis (GBA). Tryptophan is important for the growth and health of the animal and humans, and its microbial metabolism affects the interaction between gut microbiota and the GBA. By employing intestine cannulated pig model and adopting hindgut microbiota-targeting approaches either using antibiotics or increasing carbohydrate level, together with mechanistic studies in mice and neuronal cells, she demonstrates that tryptophan, and also another aromatic amino acid tyrosine, circulating in the gut, blood and brain, act as mediators between hindgut microbiota and brain neurochemistry. 

 

Targeting Microbiota 2021 Congress
October 20-22, 2021 - Paris, France & Online
www.microbiota-site.com

 

What Can the Microbiota of the Naked Mole-Rat Tell Us – The Clue to Longevity

Gerd BirkenmeierProf. Gerd Birkenmeier from the University of Leipzig, Germany, will join the Targeting Microbiota 2021 Congress and will give a presentation entitled "What Can the Microbiota of the Naked Mole-Rat Tell Us – The Clue to Longevity".



Targeting Microbiota 2021 Congress
October 20-22, 2021 - Paris, France & Online
www.microbiota-site.com

Exosomes and Microbiota: Recent Advances and Perspectives

Duncan Ross

Dr. Duncan Ross and Dr. Rainer Mutschler from Biomedical Center Speyer, Germany, will talk about Exosomes and Microbiota: Recent Advances and Perspectives.

They both confirm that exosomes, or extracellular vesicles, are nanometer lipid vesicles known to be secreted by most eukaryotic and prokaryotic cell types. Additionally, it is well known that germ free animal models lacking commensal bacteria are prone to food allergies among other types of dysfunction. The production of extracellular vesicles by gram negative and gram positive bacteria is recently being understood and are classified as outer membrane vesicles when released by Gram-negative bacteria or as membrane vesicles when released by Gram-positive bacteria. In some models, bacterial EVs alone can induce regulatory T cell formation potentially tolerizing the host to these foreign antigens. The isolation and more importantly, characterization, of these small vesicles is a rapidly evolving field. Methods such as dSTORM, High performance liquid chromatography, RNA characterization and the use of known control EVs are all critical to the creation of reproducible exosome products. Bacterial EVs can interact with host cells through three mechanisms: (1) direct activation of host receptors; (2) delivery of bacterial EV content; and (3) full incorporation of EVs into the host cell cytoplasm. TLR activation and downstream signaling will be discussed in the context of host immune responses, as well as methods of GMP manufacturing of same.

Other Speaker in the session:

Rainer Mutschler

 

 

Dr. Rainer Mutschler, Biomedical Center Speyer, Germany

 

 

Targeting Microbiota 2021 Congress
October 20-22, 2021 - Interactive Online Congress
www.microbiota-site.com

  

Reconstruction of Ancient Microbial Genomes from the Human Gut

Targeting Microbiota 2021 KosticIt is a great pleasure to announce you that Dr. Aleksandar Kostic from Harvard Medical School, USA will give a keynote talk during the Targeting Microbiota 2021 about his excellent study published in Nature concerning the "Reconstruction of Ancient Microbial Genomes from the Human Gut".

The ISM Scientific Committee stated that "Dr. Aleksandar Kostic's study is one of the most excellent study published this year".

Read more...

Critical Evaluation of Faecal Microbiome Preservation using Metagenomic Analysis

Targeting Microbiota 2021 Alena PribylThe Organizing Committee of Targeting Microbiota 2021 Congress is honored to announce the particpation of  Dr. Alena Pribyl from Microba, USA.

Dr. Pribyl will present their recent investigation on "Critical Evaluation of Faecal Microbiome Preservation using Metagenomic Analysis".

Additionally, she recently published a related article in Nature about their study.

Dr. Pribyl demonstrates that accurate preservation of faecal samples is critical as more studies seek to use the gut microbiome to identify biomarkers of disease. In her research, she undertakes an in-depth evaluation of faecal preservation methods using shotgun metagenomics to identify the best methods for use at room temperature. These methods included RNALater, OMNIGene-GUT, a dry BBL swab, LifeGuard, and a novel method for preserving faecal samples, a Copan FLOQSwab in an active drying tube (FLOQSwab-ADT). Along with her team, she further evaluated the best performing method, the FLOQSwab-ADT, at various temperatures to determine its range of use and found it maintained its performance across all temperatures.  

 

Targeting Microbiota 2021 Congress
October 20-22, 2021 - Paris, France & Online
www.microbiota-site.com

Honeybees Microbiome: Recent Advances and Perspective on Compartmentalization in the Adult Gut

Targeting Microbiota 2021 Daniele Daffonchio

Prof. Daniele Daffonchio, from King Abdullah University, Saudi Arabia, will join us at the 8th World Congress on Targeting Microbiota.

Prof. Daffonchio will talk about "Honeybees Microbiome: Recent Advances and Perspective on Compartmentalization in the Adult Gut", mainly focuing on the microbial components of forager honeybees and their compartmentalization along the gut protions. Prof. Daffonchio will explain the results of his studies and the observed changes in the distribution and abundance of microbial components in the gut.

 

Targeting Microbiota 2021 Congress
October 20-22, 2021 - Paris, France & Online
www.microbiota-site.com

 

 

 

Microbial Endocrinology as a Framework for understanding the Avian Microbiome in a Post-Antibiotic World

Targeting Microbiota 2021 Joshua LyteDr. Joshua Lyte  from USDA Agricultural Research Service, USA will join the Targeting Microbiota 2021 Congress and will give a presentation entitled "Microbial Endocrinology as a Framework for Understanding the Avian Microbiome in a Post-Antibiotic World".

In his talk, Dr. Lyte will highlight about: The poultry industry has supplemented feed with antibiotics for decades in order to improve avian growth performance, maintain intestinal health, and suppress colonization by foodborne pathogens that cause severe diseases in human consumers. With this decades-old practice of antibiotic feed supplementation rapidly coming to an end, the poultry industry is examining how the microbiome can be harnessed to promote intestinal health and prevent colonization by foodborne pathogens. The evolutionary, neurochemical-based, cross-talk between the microbiome and the host, known as microbial endocrinology, provides a framework to elucidate the mechanisms by which the microbiome influences poultry health and exclusion of foodborne pathogens. As members of the microbiota both produce and recognize the same neurochemicals that are produced by the host’s intestinal nervous system and enteroendocrine cells, use of a microbial endocrinology-based context represents a unique approach to identify relevant mechanisms as well as design interventions to promote poultry health, and ultimately human health as well.

 

Targeting Microbiota 2021 Congress
October 20-22, 2021 - Paris, France & Online
www.microbiota-site.com

Microbiota regulate social behavior via stress response neurons in the brain

Targeting Microbiota 2021 Wei Li WuDr. Wei-Li Wu from California Institute of Technology, USA will join the Targeting Microbiota 2021 Congress and give a presentation entitled "Microbiota regulate social behavior via stress response neurons in the brain".

This talk will be about: The microbiome modulates neuronal activity in specific brain regions of mice to regulate canonical stress responses and social behaviours. Specific gut bacteria can restrain the activation of the hypothalamus-pituitary-adrenal axis. The microbiome can affect social behaviours through discrete neuronal circuits that mediate stress responses in the brain.

 

Targeting Microbiota 2021 Congress
October 20-22, 2021 - Paris, France & Online
www.microbiota-site.com

Fecal Microbiota and Metabolite Profiles in IBD and IBS

Targeting Microbiota 2021 Lena OhmanProf. Lena Öhman from University of Gothenburg, Sweden will join the Targeting Microbiota 2021 Congress and will give a presentation entitled "Fecal Microbiota and Metabolite Profiles in IBD and IBS".

Prof. Öhman's research group is successfully focusing on describing gut microbiota, immune profile and the link to disease profile, as well as therapy outcome in patients with inflammatory bowel disease (IBD) and patients with with irritable bowel syndrome (IBS).

Patients with inflammatory bowel disease suffer from a chronic inflammation of the intestinal tract. The aetiology of the intestinal inflammation is still unknown but is thought to arise due to a dysregulated immune response to gut microbiota. The disease cannot be cured, although many IBD patients benefit from antibody therapy, but the effect is highly variable and at least 30% of the patients undergoing this treatment experience no clinical improvement. Today, it is not possible to predict the patients’ disease course or response to biological therapy. Hence, there is an urgent need for biomarkers predicting clinical disease course and therapeutic outcome in patients with IBD. 

Irritable bowel syndrome (IBS) is considered to be one of the most frequent clinical problems in gastroenterology with an estimated prevalence in the community between 10 to 25 %. Despite the high frequency, effective therapeutic strategies for IBS are limited with average therapeutic gains over placebo and there is a clear unmet medical need for treating IBS.

We hypothesize that gut microbiota and the immune system influence disease course and therapeutic outcome in the patients with IBD and IBS, respectively. The aim of this project is therefore to establish how gut microbiota and immune activity influence disease course and identify microbiotic and immunological indicators of therapy outcome. 

Targeting Microbiota 2021 Congress
October 20-22, 2021 - Paris, France & Online
www.microbiota-site.com

The Promise of Microbiota Modulation during COVID-19 Pandemic

Targeting Microbiota 2021 Siew NGProf. Siew C Ng from The Chinese University of Hong Kong will present her recent study entitled "The Promise of Microbiota Modulation during COVID-19 Pandemic".

During her presentation, Prof. Ng will present new data on impact of gut microbiota on post acute covid syndrome and the role of targeted microbiota modulation during SARS Cov2 Pandemic, and its relationship with COVID-19 vaccination.

Targeting Microbiota 2021 Congress
October 20-22, 2021 - Paris, France & Online
www.microbiota-site.com

Microbiota in the Press & Media

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